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Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 529-536 doi: 10.1007/s11705-017-1645-z

Abstract: oligodeoxynucleotide coded with PSMA-targeted aptamer, drug-loading domain, primer binding site and pH-sensitiveDue to the integrated pH-sensitive spacers in the nanoparticles, in an acidic environment, the cumulative

Keywords： aptamer     DNA nanoparticles     rolling circle amplification     doxorubicin     drug delivery     pH sensitive    

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The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 423-428 doi: 10.1007/s11684-007-0083-6

Abstract: This paper reported the epidemiology of the colistin-only-sensitive (COS-AB) in a tertiary teaching hospital

Keywords： identical     different     teaching hospital     genotype     colistin-only-sensitive    

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Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 298-306 doi: 10.1007/s11705-022-2212-9

Abstract: Herein, a reversible pH fluorescent sensor was developed using caffeic acid as the precursor by one-stepThe carbon dots-based sensor (CA-CDs) exhibited pH-dependent increase in fluorescence intensity and showedlinear relationship in the range of pH 6.60 and 8.00.Notably, the fluorescence sensor has a reversible response to pH change.The present study provides a simple analytical method for pH detection suitable for in vivo.

Keywords： carbon dots     two-photon imaging     pH     diabetic mice    

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Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 128-135 doi: 10.1007/s11705-021-2080-8

Abstract: The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.

Keywords： fluorescence     probes     iron     screening     library    

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Joint entity–relation knowledge embedding via cost-sensitive learning Article

Sheng-kang YU, Xue-yi ZHAO, Xi LI, Zhong-fei ZHANG

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 11,   Pages 1867-1873 doi: 10.1631/FITEE.1601255

Abstract: As a joint-optimization problem which simultaneously fulfills two different but correlated embedding tasks (i.e., entity embedding and relation embedding), knowledge embedding problem is solved in a joint embedding scheme. In this embedding scheme, we design a joint compatibility scoring function to quantitatively evaluate the relational facts with respect to entities and relations, and further incorporate the scoring function into the maxmargin structure learning process that explicitly learns the embedding vectors of entities and relations using the context information of the knowledge base. By optimizing the joint problem, our design is capable of effectively capturing the intrinsic topological structures in the learned embedding spaces. Experimental results demonstrate the effectiveness of our embedding scheme in characterizing the semantic correlations among different relation units, and in relation prediction for knowledge inference.

Keywords： Knowledge embedding     Joint embedding     Cost-sensitive learning    

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Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

John C. Radcliffe, Declan Page, Bruce Naumann, Peter Dillon

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 4, doi: 10.1007/s11783-017-0937-3

Abstract: Water sensitive urban design principles were adopted to maximise the use of the increased run-off generatedThis paper outlines how a municipal government has progressively adopted principles of Water Sensitive

Keywords： Aquifer Recharge (MAR)     Stormwater harvesting     Water recycling drinking water     Low impact development     Water sensitive    

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Sorption of tetracycline to sediments and soils: assessing the roles of pH, the presence of cadmium and

Guixiang ZHANG, Xitao LIU, Ke SUN, Ye ZHAO, Chunye LIN

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 4,   Pages 421-429 doi: 10.1007/s11783-010-0265-3

Abstract: tetracycline (TC, H L) on sediments and soils in the presence and absence of cadmium (Cd), as affected by pHLower pH facilitated TC sorption through a cation exchange mechanism, which also took place at pH valuesWhen pH was above 7, however, ligand-promoted dissolution of TC might occur due to TC weakening the Al-Oincreased TC sorption on both sediments and soils, which resulted from the decrease of equilibrium solution pH

Keywords： sorption     tetracycline (TC)     pH     cadmium (Cd)     antibiotic    

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Effect of pH on biologic degradation of

Hongjing LI, Mengli HAO, Jingxian LIU, Chen CHEN, Zhengqiu FAN, Xiangrong WANG

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 2,   Pages 224-230 doi: 10.1007/s11783-011-0314-6

Abstract: In this paper, the effect of pH on biological degradation of by alga-lysing bacteria in laboratory-scaleUnder pH 6.5, 7.5, and 8.5 conditions, the removal rates of were respectively 75.9%, 83.6%, and 78.3%It was observed that the sequence of the removal efficiencies of algae, and organic matter were pH7.5>pH 8.5>pH 6.5.

Keywords： pH     biological degradation     alga-lysing bacteria     sequencing batch biofilm reactor (SBBR)     16S rRNA        

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single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 6,   Pages 1572-1582 doi: 10.1007/s11705-021-2112-4

Abstract: High density and uniform distribution of the gold nanoparticles functionalized single-stranded DNA modified reduced graphene oxide nanocomposites were obtained by non-covalent interaction. The positive gold nanoparticles prepared by phase inversion method exhibited good dimensional homogeneity and dispersibility, which could readily combine with single-stranded DNA modified reduced graphene oxide nanocomposites by electrostatic interactions. The modification of single-stranded DNA endowed the reduced graphene oxide with favorable biocompatibility and provided the preferable surface with negative charge for further assembling of gold nanoparticles to obtain gold nanoparticles/single-stranded DNA modified reduced graphene oxide nanocomposites with better conductivity, larger specific surface area, biocompatibility and electrocatalytic characteristics. The as-prepared nanocomposites were applied as substrates for the construction of cholesterol oxidase modified electrode and well realized the direct electron transfer between the enzyme and electrode. The modified gold nanoparticles could further catalyze the products of cholesterol oxidation catalyzed by cholesterol oxidase, which was beneficial to the enzyme-catalyzed reaction. The as-fabricated bioelectrode exhibited excellent electrocatalytic performance for the cholesterol with a linear range of 7.5‒280.5 μmol·L‒1, a low detection limit of 2.1 μmol·L‒1, good stability and reproducibility. Moreover, the electrochemical biosensor showed good selectivity and acceptable accuracy for the detection of cholesterol in human serum samples.

Keywords： reduced graphene oxide     gold nanoparticles     electrochemical biosensor     cholesterol oxidase     cholesterol    

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A Cu-modified active carbon fiber significantly promoted HS and PH simultaneous removal at a low reaction

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1425-3

Abstract:

• Cu0.15-ACF performs the best for H2S and PH<

Keywords： ACF     H2S     PH3     Cu     Low temperature     Simultaneous removal    

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Decomposition of perfluorooctanoic acid by microwave-activated persulfate: Effects of temperature, pH

Yuchi LEE, Shanglien LO, Jeff KUO, Chinghong HSIEH

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 1,   Pages 17-25 doi: 10.1007/s11783-011-0371-x

Abstract: The objectives of this study were to investigate the effects of pH (pH= 2.5, 6.6, 8.8, and 10.5), chlorideMaximum PFOA degradation occurred at pH 2.5, while little or no degradation at pH 10.5.Lowering system pH resulted in an increase in PFOA degradation rate.Both high pH and chloride concentrations would result in more scavenging of sulfate free radicals and

Keywords： microwave     perfluorooctanoic acid     pH     persulfate     chloride ions     perfluorocarboxylic acids    

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Co-fermentation of waste activated sludge with food waste for short-chain fatty acids production: effect of pH

Leiyu FENG, Yuanyuan YAN, Yinguang CHEN

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 623-632 doi: 10.1007/s11783-011-0334-2

Abstract: Effect of pH ranging from 4.0 to 11.0 on co-fermentation of waste activated sludge (WAS) with food wasteThe SCFAs production at pH 6.0, 7.0, 8.0, and 9.0 and fermentation time of 4 d was respectively 5022.7, 6540.5, 8236.6, and 7911.7 mg COD·L , whereas in the blank tests (no pH adjustment, pH 8.0 (blank testThe composition of SCFAs at pH from 6.0 to 9.0 was also different from other conditions and propionicof the mixture of WAS and food waste at different pH conditions.

Keywords： waste activated sludge (WAS)     food waste     co-fermentation     short-chain fatty acids (SCFAs)     pH     synergistic    

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The effects of sensitive region over Tibetan Plateau on disastrous weather and climate and its monitoring

Xu Xiangde

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 96-107

Abstract: region for flooding, heavy rainfall, and snowstorms in a large area of eastern China, and the most sensitive

Keywords： Tibetan plateau     upstream key sensitive region     disastrous weather     early prediction and warning    

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Tuning the electronic structure of NiCoP arrays through V doping for pH-universal hydrogen evolution

Yu Lin, Jinlei Wang, Duanlin Cao, Yaqiong Gong

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5,   Pages 1134-1146 doi: 10.1007/s11705-020-2014-x

Abstract: , high-performance, and stable electrocatalysts for the hydrogen evolution reaction (HER) over wide pHdenoted as V -NiCoP/CFP) were constructed by doping V modulation on NiCoP nanosheets on CFP and used for pH-universalinspiration to rationally enhance or design new-type nonprecious metal-based, highly efficient, and pH-universal

Keywords： hydrogen evolution reaction     transition metal phosphides     pH-universal     vanadium doping     carbon fiber paper    

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Cystine-assisted accumulation of gold nanoparticles on ZnO to construct a sensitive surface-enhanced

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 1,   Pages 15-23 doi: 10.1007/s11705-022-2177-8

Abstract: This study provided a promising method to fabricate sensitive semiconductor/noble metal-based surface-enhanced

Keywords： biomineralization     cystine     semiconductor/metal composite     SERS detection     Raman detection    

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Title Author Date Type Operation

Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

Journal Article

The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

Journal Article

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Journal Article

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Journal Article

Joint entity–relation knowledge embedding via cost-sensitive learning

Sheng-kang YU, Xue-yi ZHAO, Xi LI, Zhong-fei ZHANG

Journal Article

Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

John C. Radcliffe, Declan Page, Bruce Naumann, Peter Dillon

Journal Article

Sorption of tetracycline to sediments and soils: assessing the roles of pH, the presence of cadmium and

Guixiang ZHANG, Xitao LIU, Ke SUN, Ye ZHAO, Chunye LIN

Journal Article

Effect of pH on biologic degradation of

Hongjing LI, Mengli HAO, Jingxian LIU, Chen CHEN, Zhengqiu FAN, Xiangrong WANG

Journal Article

single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive

Journal Article

A Cu-modified active carbon fiber significantly promoted HS and PH simultaneous removal at a low reaction

Journal Article

Decomposition of perfluorooctanoic acid by microwave-activated persulfate: Effects of temperature, pH

Yuchi LEE, Shanglien LO, Jeff KUO, Chinghong HSIEH

Journal Article

Co-fermentation of waste activated sludge with food waste for short-chain fatty acids production: effect of pH

Leiyu FENG, Yuanyuan YAN, Yinguang CHEN

Journal Article

The effects of sensitive region over Tibetan Plateau on disastrous weather and climate and its monitoring

Xu Xiangde

Journal Article

Tuning the electronic structure of NiCoP arrays through V doping for pH-universal hydrogen evolution

Yu Lin, Jinlei Wang, Duanlin Cao, Yaqiong Gong

Journal Article

Cystine-assisted accumulation of gold nanoparticles on ZnO to construct a sensitive surface-enhanced

Journal Article